Article Review - challenges.

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Article Review Introduction Researchers involved in development of drugs to treat Alzheimer’s disease (AD) face various challenges. AD’s successful management requires a deliberate approach not only to treat behavioral and cognitive symptoms, but also to restore and generate new neurons. Scientific researchers have proposed new approaches and treatment methods such as multi-target ligands; those include Keap1–Nrf2 regulators, HIF-1 activators, and endogenous neurogenic agents as potential drugs for AD. The paper will review an article and cover the concepts leaned including the reasons for choosing it.Article Summary As of today, no drug developed to treat AD has worked effectively; moreover, since the year 2003 new proposed treatment methods have failed. Zheng, Fridkin, and Youdim article explores the potential application of neural network medicines to treat AD. The developments of the methods have helped researchers understand complex diseases, which can help in production and development of next generation drugs. Previous drugs used targeted the bodies’ biological networks and they did not achieve required results. Some of the diseases cannot be well treated through that process and require sophisticated therapeutic ways to reduce their effects on the human brain (Zheng, Fridkin and Youdim 4).As the article states, multi target ligands act as master regulators of cell defense mechanism improving the ability of new drugs to treat AD and other diseases such as cancer.One of such medicines is Kelch like-ECH-associated protein 1 (Keap1) nuclear factor (erythroid- derived 2)-like 2 (Nrf2) regulators, that helps reduce the Oxidizing stress (OS) in the brain. OS causes degeneration of brain cells accelerating AD in affected persons. Keap 1 acts as an antioxidant, but trials for its use have faced restrictions as research indicates they may induce oxidation under unfavorable environmental conditions. Strict regulation means the medicine will take some time before it can be well accepted for treatment and use.Neurogenic agents halt neuronal damage in patients a factor that causes memory loss.According to the article, drugs that help in neuron degeneration can potentially help treat AD.Animal trials of the drugs have yielded positive results although challenges remain for use in human beings. Furthermore, side effects associated with such medicines limit their therapeutic utility in patients (Zheng, Fridkin and Youdim 6).Concept learned In the article, the authors discuss oxidation stress as a factor that causes brain loss and degeneration. The process is relevant in chemistry although some researchers do not recognize the potential effects it may have for people with AD. In our daily lives, we interact with people who use substances that may result in brain damage, understanding potential elements that may

Surname 2 result in degeneration is vital. Particularly, investigation into the role that oxidative stress plays in the development of Alzheimer disease may lead to proper clinical interventions.Reason for choosing the article Currently, there are a lot of people who suffer from AD, the lack of a treatment drug means patients lack proper care. As a result, understanding potential treatment methods that could help cure the disease is of interest to me as a student studying chemistry. Besides, because some of my relatives suffer from the disease, I have acquired clear understanding of how it works. From the knowledge obtained from reading the article, I have can advise them about the research taking place and the potential medicines proposed for the treatment of AD.

Work Cited Zheng, H., Fridkin, M., and Youdim, M. New Approaches to Treating Alzheimer’s Disease.Perspectives in Medicinal Chemistry 2015:7 1–8 doi: 10.4137/PMC.S13210.